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2026학년도 1학기 의생명시스템학부 세미나를 안내해 드립니다.
•연사: 김동하 교수(가톨릭대 의과대학 해부학과)
•제목: Epigenetic Regulation of Autophagy
•일시: 4월 23일 목요일 오후 4시 30분
•장소: 벤처관 711호
•초록: Autophagy is a critical catabolic process regulated by nutrient-specific transcriptional and epigenetic mechanisms to maintain cellular homeostasis. This study identifies two distinct signaling axes tailored to different starvation stresses. Under glucose starvation (GS), CARM1 methylates the Pontin chromatin-remodeling factor, which then recruits the Tip60 histone acetyltransferase to FOXO3a-target autophagy genes. This CARM1-Pontin-FOXO3a axis enhances H4 acetylation at both promoter and distal enhancer regions to activate autophagy. Conversely, under amino acid starvation (AAS), single-cell RNA sequencing and trajectory analysis identified C/EBPg as a specific regulator of autophagy. While C/EBPg is essential for AAS-induced autophagy, it is dispensable under GS, with its specificity coordinated by ATF4. Together, these findings reveal that cells employ stimulus-specific epigenetic (CARM1-Pontin) and transcriptional (C/EBPg-ATF4) networks to precisely orchestrate autophagy in response to diverse nutrient deficiencies.