•연구자: 화학과 김종훈
•발표일: 2026.3.18
•DOI: https://doi.org/10.1021/acs.orglett.6c00141
•Jinju Kim et al., Organic Letters (Q1), Volume 28, 3701-3706 (2026)
•Abstract
We report the design and synthesis of a novel pyrido[1,2-a]indole fluorophore that exhibits deep-red emission (up to 660 nm), a large Stokes shift (6118 cm–1) in methanol, and excellent biocompatibility. Positional nitration enables systematic modulation of the photophysical properties across a series of regioisomers. Spectroscopic analyses and calculations revealed the intramolecular charge transfer (ICT) and rotation-induced quenching behavior. The fluorophores showed exceptional lipid droplet (LD) labeling capability in live-cell imaging without washing steps, indicating their potential for biomedical applications. This study demonstrates that simple nitro-group relocation on a compact heteroaromatic scaffold provide tunable, environment-sensitive fluorophores for probe development.