•연구자: 의생명시스템학부 임도환
•발표일: 2023.08.14
•DOI: https://doi.org/10.3390/insects14080709
•Hee Kyung Kim et al., Insects (Q1); Volume 14, Issue 8, 709. (2023)
•Abstract
In animals, including humans and flies, blood cells play crucial roles in various biological processes, such as immune response and normal development. The abnormal regulation of hematopoiesis in flies results in the formation of melanotic masses, which are also known as melanotic tumors. However, the detailed mechanisms underlying this process are not fully understood. In this study, we found that the upregulation of miR-274-5p, a small non-coding RNA, activates the JNK and JAK/STAT signaling pathways by suppressing the expression of found-in-neurons (fne) encoding an RNA-binding protein in flies. This regulation controls the formation of melanotic masses and developmental growth. Overall, our findings provide valuable insights into melanotic mass formation and developmental growth as well as the regulatory network of the JNK and JAK/STAT signaling pathways.